翻訳と辞書 Words near each other ・ Cis-2-Decenoic acid ・ Cis-2-enoyl-CoA reductase (NADPH) ・ Cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase ・ Cis-3-Hexen-1-ol ・ Cis-3-Hexenal ・ Cis-3-Methyl-4-octanolide ・ Cis-abienol synthase ・ Cis-acting replication element ・ Cis-Dichlorobis(ethylenediamine)cobalt(III) chloride ・ Cis-dihydroethylcatechol dehydrogenase ・ CIS-EMO ・ Cis-Gomti area ・ Cis-Inositol ・ Cis-Lunar ・ Cis-muuroladiene synthase ・ Cis-natural antisense transcript ・ Cis-Neptunian object ・ Cis-p-coumarate glucosyltransferase ・ Cis-Regulatory element ・ Cis-regulatory module ・ Cis-Sutlej states ・ Cis-trans isomerase ・ Cis-zeatin O-beta-D-glucosyltransferase ・ CIS/CCA Curling Championships ・ CISA ・ Cisa Pass ・ CISA-DT ・ CISAC ・ Cisadane River ・ Cisai-Saint-Aubin Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Cis-natural antisense transcript ： ウィキペディア英語版 Cis-natural antisense transcript Natural antisense transcripts (NATs) are a group of RNAs encoded within a cell that have transcript complementarity to other RNA transcripts. They have been identified in multiple eukaryotes, including humans, mice, yeast and ''Arabidopsis thaliana''. This class of RNAs includes both protein-coding and non-coding RNAs. Current evidence has suggested a variety of regulatory roles for NATs, such as RNA interference (RNAi), alternative splicing, genomic imprinting, and X-chromosome inactivation. NATs are broadly grouped into two categories based on whether they act in cis or in trans. Trans-NATs are transcribed from a different location than their targets and usually have complementarity to multiple transcripts with some mismatches. MicroRNAs (miRNA) are an example of trans-NATs that can target multiple transcripts with a few mismatches.〔 Cis-natural antisense transcripts (cis-NATs) on the other hand are transcribed from the same genomic locus as their target but from the opposite DNA strand and form perfect pairs. == Orientation of cis-NATs == Cis-NATs have a variety of orientations and differing lengths of overlap between pairs.〔 There have been five identified orientations for cis-NATs to date. The most common orientation is head-to-head, where the 5' ends of both transcripts align together.〔 This orientation would result in the greatest knockdown of gene expression if transcriptional collision is the reason for transcript inhibition.〔 There are however some studies that have suggested that tail-to-tail orientations are the most common NAT pairs.〔 Others such as tail to tail, overlapping, nearby head-to- head, and nearby tail-to-tail are less frequently encountered.〔 Completely overlapping NATs involve the antisense gene being located completely over top of each other.〔 Nearby head-to-head and tail-to-tail orientations are physically discrete from each other but are located very close to each other.〔 Current evidence suggests that there is an overrepresentation of NAT pairs in genes that have catalytic activity.〔 There may be something about these genes in particular that makes them more prone to this type of regulation. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cis-natural antisense transcript」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.